GLIPR1 Polyclonal Antibody (CAB16490)

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CAB16490
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Description

Antibody DatasheetAntibody MSDS

GLIPR1 Polyclonal Antibody (CAB16490)

Overview

Title:GLIPR1 Polyclonal Antibody (CAB16490)
Size:100µL
Code:CAB16490
Host Species:Rabbit
Purification:Affinity purification
Isotype:IgG

Background

This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Immunogen Information

Immunogen:Recombinant funsion protein containing a sequence corresponding to amino acids 22-140 of human GLIPR1 (NP_006842.2).
GeneID:11010
SwissProt:P48060
Synonyms:GLIPR1; CRISP7; GLIPR; RTVP1; GLI pathogenesis related 1
Calculated MW:26kDa/30kDa
Observed MW:28kDa

Applications

Reactivity:Rat
Tested Applications:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting    
Positive Samples:Rat lung
Cellular Location:Membrane, Single-pass membrane protein

Antibody Images

Western blot - GLIPR1 Polyclonal Antibody (CAB16490)

Western blot analysis of extracts of rat lung, using GLIPR1 antibody (CAB16490) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

GLIPR1 Polyclonal Antibody (CAB16490) Protein Information

UniProt Protein Function:GLIPR1: a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q21.2

Cellular Component: membrane; plasma membrane

Biological Process: neutrophil degranulation; regulation of lipid metabolic process

NCBI Summary:This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:P48060
NCBI GenInfo Identifier:110825980
NCBI Gene ID:11010
NCBI Accession:NP_006842.2
UniProt Secondary Accession:P48060,Q15409, Q969K2, A7YET6, F8VUC2,
UniProt Related Accession:P48060
Molecular Weight:28.2kD
NCBI Full Name:glioma pathogenesis-related protein 1
NCBI Synonym Full Names:GLI pathogenesis related 1
NCBI Official Symbol:GLIPR1  
NCBI Official Synonym Symbols:GLIPR; RTVP1; CRISP7  
NCBI Protein Information:glioma pathogenesis-related protein 1
UniProt Protein Name:Glioma pathogenesis-related protein 1
UniProt Synonym Protein Names:Protein RTVP-1
Protein Family:GDSL esterase/lipase
UniProt Gene Name:GLIPR1  
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Additional Information

Product type:
Antibody
Application:
WB
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
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